Journal of Applied Physiology AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 39: 76-85, 1975;
8750-7587/75 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Phillipson, E. A.
Right arrow Articles by Schultze, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Phillipson, E. A.
Right arrow Articles by Schultze, R. K.

Journal of Applied Physiology, Vol 39, Issue 1 76-85, Copyright © 1975 by American Physiological Society

ARTICLES

Role of vagal stimuli in exercise ventilation in dogs with experimental pneumonitis

E. A. Phillipson, E. Murphy, L. F. Kozar and R. K. Schultze

We have investigated the possibility that afferent vagal stimuli may be responsible for the excessive ventilatory drive during exercise characteristic of many diffuse pulmonary parenchymal diseases. Studies were performed on four conscious dogs with cervical vagal loops, in whom experimental pneumonitis was induced by the intravenous administration of complete Freund's adjuvant. Control measurements were made over a 3-mo interval prior to induction of disease which then ran a course of 6 wk. The disease was characterized histologically by a diffuse interstitial pneumonitis during the first week, and by a proliferative granulomatosis during the subsequent 4-5 wk. Physiologic disturbances at rest included decreased total lung and functional residual capacities; increased lung elastic recoil; and decreased carbon monoxide diffusing capacity. During mild-to-moderate steady-state exercise, the minute volume of ventilation (VE) and respiratory frequency (f) were increased significantly compared to control values; tidal volume (VT) was decreased significantly; and exercise tolerance (ET) was impaired. Complete cervical vagal blockade abolished the abnormally high VE, decreased f, and increased VT in all dogs, and improved ET in at least two dogs. The results indicate that afferent vagal stimuli were responsible for the excessive ventilation during exercise and contributed to the abnormal pattern of breathing.


This article has been cited by other articles:


Home page
 ChestHome page
M. H. Lavietes, C. M. Gerula, K. G. Fless, N. S. Cherniack, and R. R. Arora
Inspiratory Muscle Weakness in Diastolic Dysfunction
Chest, September 1, 2004; 126(3): 838 - 844.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. D. PARKER, D. BROOKS, L. F. KOZAR, C. L. RENDER-TEIXEIRA, R. L. HORNER, T. DOUGLAS BRADLEY, and E. A. PHILLIPSON
Acute and Chronic Effects of Airway Obstruction on Canine Left Ventricular Performance
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 1888 - 1896.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online