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J Appl Physiol 39: 60-65, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 39, Issue 1 60-65, Copyright © 1975 by American Physiological Society


ARTICLES

Influence of expiratory flow on closing capacity at low expiratory flow rates

J. R. Rodarte, R. E. Hyatt and D. A. Cortese

Single-breath oxygen (SBO2) tests at expiratory flow rates of 0.2, 0.5, and 1.01/s were performed by 10 normal subjects in a body plethysmograph. Closing capacity (CC)--the absolute lung volume at which phase IV began--increased significantly with increases in flow. Five subjects were restudied with a 200-ml bolus of 100% N2 inspired from residual volume after N2 washout by breathing 100% O2 and similar results were obtained. An additional five subjects performed SBO2 tests in the standing, supine, and prone positions; closing volume (CV)--the lung volume above residual volume at which phase IV began--also increased with increases of expiratory flow. The observed increase in CC with increasing flow did not appear to result from dependent lung regions reaching some critical "closing volume" at a higher overall lung volume. In normal subjects, the phase IV increase in NI concentration may be caused by the asynchronous onset of flow limitation occurring initially in dependent regions.


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