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J Appl Physiol 38: 1088-1091, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 38, Issue 6 1088-1091, Copyright © 1975 by American Physiological Society

ARTICLES

Nitrogen and bolus closing volumes: differences after histamine-induced bronchoconstriction

M. K. Benson, L. A. Newberg and J. G. Jones

Studies in normal subjects have shown that there is little difference in the size of the closing volume when measured by either the nitrogen methods or a bolus method. In this study we have examined the changes in closing volume following histamine-induced bronchoconstriction. In five normal subjects histamine resulted in a reduction in the vital capacity, an increase in the residual volume, and an increase in the airway resistance. The size of the closing volume measured by a bolus method increased after induced bronchoconstriction (0.52 +/- 0.15 1 to 0.74 +/- 0.17 1). With the nitrogen method the closing volume became smaller (0.51 +/- 0.19 1 to 0.17 +/- 0.17 1). Similar differences between the two methods are demonstrated in patients with asthma. The suggested explanation for these differences lies in the different methods used to establish a concentration gradient of gas in the lung. If there is "air trapping" the nitrogen method may fail to establish a concentration gradient.


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