Journal of Applied Physiology AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 38: 882-885, 1975;
8750-7587/75 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yhap, E. O.
Right arrow Articles by Alix, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yhap, E. O.
Right arrow Articles by Alix, E. C.

Journal of Applied Physiology, Vol 38, Issue 5 882-885, Copyright © 1975 by American Physiological Society

ARTICLES

Decreased oxygen uptake with stored blood in the isolated hindlimb

E. O. Yhap, C. B. Wright, N. A. Popovic and E. C. Alix

Storage of red cells in acid-citrate-dextrose (ACD) solution for more than a week has been shown to cause a reduction in red cell 2,3-diphosphoglycerate (2,3-DPG), resulting in a decrease in the half-saturation pressure (P50) of stored blood, thus increasing hemoglobin-oxygen affinity and theoretically decreasing oxygen delivery to the tissues. A method to isolate and perfuse the hindlimb in a dog has been developed and used successfully to compare the difference of oxygen release between banked and fresh ACD blood. Ten dogs were perfused using canine blood collected in standard blood transfusion bags containing ACD and stored at 4 degrees C and fresh blood collected in a similar manner but used immediately. The total oxygen release in the limb during perfusion with fresh blood was significantly greater than during perfusion with stored blood.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. E. Curtis, T. A. Walker, W. E. Bradley, and S. M. Cain
Raising P50 increases tissue PO2 in canine skeletal muscle but does not affect critical O2 extraction ratio
J Appl Physiol, November 1, 1997; 83(5): 1681 - 1689.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online