Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 38: 786-775, 1975;
8750-7587/75 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muir, A. L.
Right arrow Articles by Brash, H. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muir, A. L.
Right arrow Articles by Brash, H. M.

Journal of Applied Physiology, Vol 38, Issue 5 786-775, Copyright © 1975 by American Physiological Society

ARTICLES

Cardiorespiratory effects of rapid saline infusion in normal man

A. L. Muir, D. C. Flenley, B. J. Kirby, M. F. Sudlow, A. R. Guyatt and H. M. Brash

We have studied the cardiorespiratory effects of the rapid infusion (100 ml/min) of 2 liters of saline in four normal seated subjects. Cardiac output and pulmonary arterial pressure increased, while vital capacity (VC) and total lung capacity (TLC) decreased. There was an increase in closing volume (CV) without any detectable change in lung compliance or flow-volume characteristics. There was an increase in Pao2 during infusion period which can be related to better matching of ventilation to perfusion and to improved hemoglobin transport. In the recovery stage as cardiac output, pulmonary arterial pressure, TLC, and VC all returned toward control values CV remained high. In two subjects CV occurred within the normal tidal range of ventilation and in these two subjects Pao2 fell significantly below values obtained in the control period. The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. Pellegrino, R. Dellaca, P. T. Macklem, A. Aliverti, S. Bertini, P. Lotti, P. Agostoni, A. Locatelli, and V. Brusasco
Effects of rapid saline infusion on lung mechanics and airway responsiveness in humans
J Appl Physiol, August 1, 2003; 95(2): 728 - 734.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Duguet, C. Tantucci, O. Lozinguez, R. Isnard, D. Thomas, M. Zelter, J.-P. Derenne, J. Milic-Emili, and T. Similowski
Expiratory flow limitation as a determinant of orthopnea in acute left heart failure
J. Am. Coll. Cardiol., March 1, 2000; 35(3): 690 - 700.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Puri, D. P. Dutka, B. L. Baker, J. M. B. Hughes, and J. G. F. Cleland
Acute Saline Infusion Reduces Alveolar-Capillary Membrane Conductance and Increases Airflow Obstruction in Patients With Left Ventricular Dysfunction
Circulation, March 9, 1999; 99(9): 1190 - 1196.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online