Journal of Applied Physiology Journal of Neurophysiology
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J Appl Physiol 38: 702-709, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 38, Issue 4 702-709, Copyright © 1975 by American Physiological Society

ARTICLES

Total work rate of breathing optimization in CO-2 inhalation and exercise

S. M. Yamashiro, J. A. Daubenspeck, T. N. Lauritsen and F. S. Grodins

The hypothesis that respiratory frequency and the relative durations of inspiration and expiration are regulated according to a total cycle work rate minimization criterion was explored. Effects of negative work performed by the respiratory muscles and dead space variation as a function of tidal volume were included in a formulation which yielded a theoretically predictable optimal frequency and relative duration of inspiration and expiration at all levels of ventilation. Predicted cycle characteristics based on measured mechanical parameters were compared with data taken during CO-2 inhalation (3 and 5%) and moderate exercise (MRR = 3 and 6) in three normal human subjects. No major difference in breathing pattern was observed between CO-2 inhalation and exercise. Results suggest that conditions for minimization of total cycle work rate are achieved asympototically as the level of ventilation rises above the resting level. At rest and at low levels of hyperpnea complete work rate optimization is not achieved.


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