Journal of Applied Physiology, Vol 38, Issue 4 696-701, Copyright © 1975 by American Physiological Society
Circulation in rats with Guerin carcinoma
L. Takacs, L. A. Debreczeni and C. Farsang
After implantation of Guerin carcinoma in rats, cardiac output (by
Evans-blue dilution), distribution of the organ fractions of cardiac output
(by Sapirsteins's isotope indicator fractionation technique), nutritive
blood flow and circulatory resistance of the organs (including the tumor)
were studied. The following parameters were altered proportionately to the
weight of the tumor (0.39-84.0 g): a) weight of gut and carcass diminished;
b) cardiac index increased, blood pressure and total peripheral resistance
decreased; c) tumor fraction of cardiac output was augmented; d) blood flow
of the organs increased and their circulatory resistance decreased.
Hematocrit decreased from 47.2 to 31.0% 20 days after tumor implantation.
In rats with tumor the changes of blood flow may be conditioned by both
anemia and the decrease in organ weight.
