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J Appl Physiol 38: 538-539, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 38, Issue 3 538-539, Copyright © 1975 by American Physiological Society

ARTICLES

A safe and fast-acting surgical anesthetic for use in the guinea pig

D. W. Shucard, M. Andrew and C. Beauford

Ketamine [dl-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone] hydrochloride was used in conjunction with Acepromazine [10-3-(dimethylamino)-propyl]phenothiazin-2-yl-methyl ketone] Maleate to produce surgical depth anesthesia in guinea pigs. In tests with 97 animals, an intramuscular injection of 44 mg/kg ketamine hydrochloride plus 2 mg Acepromazine Maleate was found to be effective in producing a surgical level of anesthesia within 2 min after administration. The anesthetic state lasted for an average of 1.5 h and could be safely extended by supplemental administrations of the drugs. This anesthetic combination was found to be fast acting, safe, and easily controlled.




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