Journal of Applied Physiology, Vol 38, Issue 2 282-287, Copyright © 1975 by American Physiological Society
Excretion of retained fluoride in man
H. Spencer, L. Kramer, D. Osis and E. Wiatrowski
In fluoride studies performed in man the excess fluoride excretions in
urine and stool over and above the base-line excretions were determined
following the discontinuation of fluoride supplements. The fluoride
supplements contained either 9.1 mg fluoride as sodium fluoride, given
daily for 32 days, or 7.6 mg fluoride as fish protein concentrate (FPC),
given daily for 26 days. Following discontinuation of these fluoride
supplements the excess fluoride excretions were low and of short duration,
in most cases for 6-12 days. Since the fluoride supplements were given for
a known period of time, the fluoride retention could be calculated from the
fluoride balances, and the excess fluoride excretion corresponded to 9.1%
of the retained fluoride given as NaF and to 14.1% of the retained fluoride
given as FPC. The excess fluoride was predominantly excreted via the
kidney, i.e., 87% of the total excess fluoride excretion was passed in
urine and only 13% in stool.
