Journal of Applied Physiology
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J Appl Physiol 38: 16-19, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 38, Issue 1 16-19, Copyright © 1975 by American Physiological Society

ARTICLES

Ventilatory effects of hypoxia and their dependence on PCO2

A. S. Rebuck and W. E. Woodley

In 11 healthy subjects the effect of progressive hypoxia on pulmonary ventilation at various alveolar carbon dioxide pressures was studied. A rebreathing technique was used to produce hypoxia, CO2 was held constant and oxygen saturation was taken as the independent variable. We found a linear relationship between ventilation and falls in oxygen saturation when Pco2 was held at the resting mixed venous, end-tidal, or any intermediate level. Within this range of Pco2, a family of ventilation-So2 response curves was obtained for each subject. The effect of altering the isocapnic level was to change the slope and position of the ventilation-So2 response curve, the amount by which the slope changed being related to the slope for that subject at their mixed venous Pco2.


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