Quantitation of collagen in the wall of the human urinary bladder

Page 122: Swaiman, Kenneth F., and William E. Bradley, "Quantitation of collagen in the wall of the human urinary bladder." The first paragraph should read:

Clinicians visually assess skeletal muscle atrophy and by clinical testing evaluate muscle weakness. Similar direct assessment of muscle function is not applicable to the detrusor muscle of the urinary bladder. The slow fill cystometrogram is useful in detecting reflex abnormalities and the physical state of the bladder wall but does not quantitate muscle loss and fibrotic replacement (10). Diagnostic aid may be obtained by histologic examination of detrusor muscle biopsies. However, neither of these techniques measure smooth muscle depletion and collagen replacement secondary to neurologic vesical dysfunction and its sequelae of inflammation and fibrosis (2).