Journal of Applied Physiology AJP: Advances in Physiology Education
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J Appl Physiol 20: 919-921, 1965;
8750-7587/65 $5.00
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Venous admixture in dogs with chronic pulmonary hypertension

Dusan Kentera 1, Charles R. Wallace 1, William F. Hamilton 1, and Lois T. Ellison 1

1 Department of Physiology, Medical College of Georgia, Augusta, Georgia

In dogs with chronic pulmonary hypertension due to infestation with Dirofilaria immitis (heartworm disease) positive correlation was found between the rise in mean pulmonary arterial pressure and the increase in venous admixture. No abnormality was observed in pulmonary diffusing capacity or pulmonary capillary blood volume and results were essentially the same in the normotensive and hypertensive animals. Increased venous admixture in dogs with high pulmonary artery pressure was explained by increased flow through arteriovenous shunts in the lungs. Hypoventilation, atelectasis with perfusion of unventilated alveoli, and anatomical shunting through patent ductus arteriosus or foramen ovale were eliminated as causes. The possible importance of this phenomenon from the standpoint of survival is mentioned.

pulmonary capillary blood volume; variation in pulmonary; arteriovenous shunts; pulmonary diffusing capacity; dirofilariasis and pulmonary circulation; heartworm disease and pulmonary circulation; pulmonary diffusion and chronic pulmonary hypertension; surface tension

Submitted on February 26, 1965






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