Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 20: 912-918, 1965;
8750-7587/65 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lawson, W. H.
Right arrow Articles by Forster, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lawson, W. H., JR.
Right arrow Articles by Forster, R. E.

Effect of temperature on deoxygenation rate of human red cells

W. H. Lawson JR. 1, R. A. B. Holland 1, and R. E. Forster 1

1 Department of Physiology, Graduate School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

The rate of deoxygenation of oxygenated human red cell suspensions was measured in vitro as a function of temperature from 7 to 42 C at constant Pco2 in a stopped-flow rapid-reaction apparatus. There is a linear relationship between the deoxygenation rate constant, kc, and the reciprocal of the absolute temperature; the "activation energy" of 16,743 cal/mole agreed reasonably well with that predicted by theory, 14, 565. At 42 C deoxygenation was half complete in 0.04 sec while at 7 C the half-time was slowed to 0.8 sec. If the red cell transit time in tissues cooled to 7 C approximates the normally accepted value at 37 C of about 1 sec, the rate of red cell deoxygenation would be a limiting factor in the supply of oxygen to the peripheral tissues in the cold.

capillary diffusion; respiration; stopped-flow rapid-reaction apparatus

Submitted on May 14, 1964




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. V. Kondratiev, K. Flemming, E. S. P. Myhre, M. A. Sovershaev, and T. Tveita
Is oxygen supply a limiting factor for survival during rewarming from profound hypothermia?
Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H441 - H450.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online