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J Appl Physiol 20: 628-636, 1965;
8750-7587/65 $5.00
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Effects of unilateral thoracic irradiation on lung function

Charles D. Teates 1

1 Department of Physiology, School of Medicine, University of Virginia, Charlottesville, Virginia

Five dogs were irradiated in one hemithorax with 4,500 R midlung dose over 23–27 days. Function of each lung was studied prior to irradiation and at frequent intervals up to 207 days after irradiation. A nonspecific reduction in function of the irradiated lung was reflected on all indices. The reduction in diffusion capacity apparently resulted from factors other than alveolar-capillary block. Pulmonary function did not improve during the period studied. Pathologic, radiologic, and physiologic studies showed considerable variation of damage from one animal to another and within the same lung, but each subject showed change of some degree.

X-irradiation; lung pathology

Submitted on October 2, 1964




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Ann Intern Med, January 1, 1977; 86(1): 81 - 92.
[Abstract] [PDF]


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