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J Appl Physiol 20: 27-30, 1965;
8750-7587/65 $5.00
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Acid-base constants and temperature coefficients for cerebrospinal fluid

Robert A. Mitchell 1, Dorothy A. Herbert 1, and Charles T. Carman 1

1 Department of Anesthesia, Department of Medicine, and Cardiovascular Research Institute, University of California Medical Center, San Francisco, California

The solubility of CO2 in human cerebrospinal fluid (CSF) is 0.0312 mmole/liter·mm Hg at 38 C. The first dissociation constant (pK1') of carbonic acid at 38 C is 6.130 at pH 7.30 and varies inversely with pH and temperature. At pH 7.30 DeltapK1'/ DeltapH is –0.050 and DeltapK1'/DeltaT is –0.0029 U/°C. pH of CSF varies inversely with temperature over the range of pH from 6.9 to 7.7. DeltapH/DeltaT is –0.0037 U/°C. The temperature correction for CSF Pco2 is expressed Pco2T1/Pco2T2 = 10f(T1–T2) At pH 7.30, f is 0.0110. The effect of varying Pco2 on pH in vitro at 38°C, expressed as Delta log Pco2/DeltapH, is 1.063 ± 0.022.

first dissociation constant; CO2 solubility; CSF buffering

Submitted on February 20, 1964




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