Journal of Applied Physiology
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J Appl Physiol 20: 16-18, 1965;
8750-7587/65 $5.00
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Variations in cardiac output associated with hemoglobin levels in anesthetized sheep

D. F. J. Halmagyi 1, B. Starzecki 1, and G. J. Horner 1

1 The Gordon Craig Research Laboratory, Department of Surgery, University of Sydney, Sydney, Australia

Hemoglobin levels in sheep was found to be related inversely to the logarithm of cardiac index and directly to the calculated systemic and pulmonary arterial resistances over a wide spectrum of hemoglobin concentrations including the normal range. It appeared to be based on changes in blood viscosity produced by a varying red cell concentration. The continuous adjustment of hemoglobin levels and cardiac output may account for the variability of cardiac output values in normal laboratory animals and may represent a mechanism maintaining oxygen delivery to the tissues in the presence of changing oxygen carrying capacity.

blood viscosity; vascular resistance; oxygen carrying capacity

Submitted on May 15, 1964






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