Renal clearances at rest and during physical exercise after injection of bacterial pyrogen

¹ Department of Clinical Physiology, University of Göteborg, Göteborg, Sweden

Clearance of inulin (C_In) and para-aminohippuric acid (C_PAH), cardiac output, oxygen uptake, and arterial blood pressure were measured in five healthy subjects at rest and during supine exercise on a bicycle ergometer before and after injection of a bacterial pyrogen (purified lipopolysaccharide, Pyrexal). C_PAH was 45–145% higher at rest during the flush phase than in the normal condition. The increase in C_In, was less. Cardiac output increased also. The renal fraction of the cardiac output was larger than in the normal condition. During moderate exercise in the flush phase, C_PAH decreased from the values before work. This decrease was usually larger than in the normal condition. The pyrogen-induced increase in cardiac output was less during exercise than at rest. A pronounced renal vasoconstriction during exercise is demonstrated even after the injection of bacterial pyrogen.

Submitted on May 4, 1964