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J Appl Physiol 20: 113-116, 1965;
8750-7587/65 $5.00
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Pulmonary diffusing capacity and capillary blood volume in normal and anemic dogs

Denise Jouasset-Strieder 1, John M. Cahill 1, John J. Byrne 1, and Edward A. Gaensler 1

1 Third Surgical Research Laboratory, Boston City Hospital, and Thoracic Services, Massachusetts Memorial Hospitals, Boston University Medical Center, Boston, Massachusetts

The CO diffusing capacity (Dl) was measured by the single-breath method in eight anesthetized dogs. Pulmonary capillary blood volume (Vc) and membrane diffusing capacity (Dm) were determined in six animals by the method of Roughton and Forster. The studies were repeated after anemia had been induced by replacing whole blood with plasma. Large dogs were selected with a mean body weight of 29 kg and a mean alveolar volume of 2,020 ml (STPD) during tests. The mean arterial blood Hb decreased from 14.3 to 6.6 g/100 ml, the mean Dl from 27 to 12 ml/min mm Hg, and the mean Dm from 100 to 47 ml/min mm Hg. Vc averaged 67 ml in the control state and was not significantly changed during anemia. Reductions in Dl and Dm during anemia were proportional to the fall in blood Hb. Both Dl and Dm in all dogs, normal and anemic, were proportional to the volume of red blood cells in the lung capillaries (Vrbc). These results suggest that Vrbc might be an estimate of the useful area of the alveolar-capillary membrane while Dm/Vrbc should vary with changes in its thickness. The latter was not altered by anemia.

alveolar capillary membrane; pulmonary membrane; diffusing capacity; pulmonary capillary RBC volume; pulmonary diffusion pathway; carbon monoxide

Submitted on March 2, 1964






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