Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 19: 897-900, 1964;
8750-7587/64 $5.00
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Influence of temperature on blood pH of the human adult and newborn

Karlis Adamsons JR. 1, Salha S. Daniel 1, Gillian Gandy 1, and L. Stanley James 1

1 Departments of Obstetrics and Gynecology, Anesthesiology, and Pediatrics, College of Physicians and Surgeons, Columbia University, and Divisions of Obstetrics and Gynecology (Sloane Hospital), Anesthesiology and Pediatrics (Babies Hospital), Presbyterian Hospital, New York City

The effect of temperature upon pH of blood from adult and newborn humans was investigated. Although the mean DeltapH/DeltaT values for the two populations differed, 0.0144/ °C for adults versus 0.0128 for the newborn, this was not peculiar to the source since the temperature-induced pH changes were identical when comparison was made between samples of similar pH and CO2 content. It was shown that even over the physiologic pH range DeltapH/DeltaT is not constant but is a function of pH and CO2. No significant changes in DeltapH/DeltaT were observed with oxygenation of hemoglobin. The influence of red cell concentration was detectable only when hematocrit values fell below 20%. A graph and an equation for the determination of DeltapH/DeltaT of blood with a given pH and CO2 content is presented.

acid base

Submitted on December 9, 1963




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P. ASTRUP and K. ENGEL
Acid-Base Problems in Hypothermia
Arch Intern Med, November 1, 1965; 116(5): 739 - 742.
[Abstract] [PDF]


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