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J Appl Physiol 19: 353-356, 1964;
8750-7587/64 $5.00
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Evaluation by dye dilution of the pressure-slope method for peripheral run-off

Heinz P. Pieper 1 and Sidney D. Leverett 1

1 Department of Physiology, Ohio State University, Columbus, Ohio

The reliability of the pressure-slope method for the calculation of peripheral run-off rate has been demonstrated using the dye-dilution technique. The pressure-slope method yields a plot of peripheral run-off rate versus arterial pressure, for a given set of cardiovascular conditions. Under steady-state conditions, the peripheral runoff rate (total arterial outflow) must equal the cardiac output. Thus, a dye-dilution value for cardiac output was correlated with the mean arterial pressure at which it was determined, and then compared to the peripheral run-off rate at the same pressure. The results support the application of the pressure-slope method for the calculation of peripheral run-off rate (and also for the determination of cardiac output) in intact anesthetized dogs.

total arterial outflow; cardiac output determination; pressure-flow relationships in the arterial system

Submitted on December 17, 1962






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