Journal of Applied Physiology
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J Appl Physiol 19: 322-324, 1964;
8750-7587/64 $5.00
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Measurement of total pressure of dissolved gas in mammalian tissue in vivo

Michael T. Lategola 1

1 Biodynamics Branch, Civil Aeromedical Research Institute, Federal Aviation Agency, Oklahoma City, Oklahoma

An in vivo method for the quantitative estimation of total gas pressure in mammalian tissue has been established. This method utilizes a rigid-walled capsule specially constructed to be permeable to O2, CO2, and N2, but negligibly permeable to water vapor. The results obtained, after subcutaneous implantation of this capsule, directly demonstrate that the total gas pressure in the adjacent tissue interface is about 40–50 mm Hg less than the concomitant atmospheric pressure. This pressure difference is a result of the metabolic gas exchange of the tissue interface.

tissue metabolism; blood-gas tensions; tissue-blood gas diffusion; gas-bubble physiology; dog tissues total gas pressure

Submitted on July 25, 1963






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