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J Appl Physiol 18: 1105-1110, 1963;
8750-7587/63 $5.00
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Control mechanisms in blood fluidity: role of adenosine triphosphate

L. O. Pilgeram 1 and D. A. Loegering 1

1 Arteriosclerosis Research Laboratory, St. Barnabas Hospital Research Foundation, and Department of Physiology, University of Minnesota School of Medicine, Minneapolis, Minnesota

A possible role for cellular energy metabolism in the control of the blood clotting mechanism has been shown. High-energy phosphate was found to strongly inhibit the recalcification time of plasma prepared with siliconized or glass surfaces. The nucleotide, adenosine triphosphate, in crystalline form and chromatographically pure, will inhibit or completely prevent coagulation in vitro. Reactivity is based primarily on the high-energy phosphate linkage and secondarily upon the nucleoside, adenosine. The principal site of action for ATP is on an unidentified precursor of thromboplastin. Available evidence indicates an important role for energy metabolism in the cellular mechanisms which effect a control over thromboplastin generation and its possible thrombotic and arteriosclerotic sequelae.

cellular control mechanisms; blood fluidity; thrombosis arteriosclerosis; aging

Submitted on July 1, 1963






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