Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 18: 1079-1084, 1963;
8750-7587/63 $5.00
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Calcium phosphorus metabolism in man during acclimatization to carbon dioxide

K. E. Schaefer 1, G. Nichols JR. 1, and C. R. Carey 1

1 U. S. Naval Medical Research Laboratory, U. S. Naval Submarine Base, New London, Groton, Connecticut

The calcium phosphorus metabolism was studied in 20 subjects who were exposed for 42 days to 1.5% CO2. Plasma calcium mirrored the changes of the pH, showing a decrease during the first 23 days of exposure, a return to initial levels during the latter part of exposure, a marked rise above control values during the 8–9 day recovery period following exposure, and a return to normal values after 4 weeks of recovery. Changes in plasma calcium were found to correspond to changes in pulmonary CO2 excretion indicating a significant role of bone CO2 stores in acclimatization and deacclimatization of carbon dioxide. Plasma inorganic phosphorus was elevated throughout the exposure period and recovery period. At the end of the exposure period to CO2 red cell calcium had increased and red cell phosphorus had decreased. After 9 days, as well as after 4 weeks, of recovery on air the calcium content of the red cells continued to increase and the inorganic phosphorus values remained lowered.

chronic respiratory acidosis; chronic hypercapnia

Submitted on November 2, 1961




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