Journal of Applied Physiology
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J Appl Physiol 18: 955-958, 1963;
8750-7587/63 $5.00
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Relationship between ambient temperature and acetylating capacity of human blood

S. H. Blondheim 1, Gabriel Neumann 1, Edna Kott 1, and Zena Ben-Ishai 1

1 Metabolic Laboratory and Department of Internal Medicine B, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel

The ability of human blood to acetylate p-aminobenzoic acid, determined in vitro, varied directly with the ambient temperature to which the subject was exposed before the blood was drawn. This was demonstrated by 135 determinations of the acetylating ability of the blood of 49 subjects performed over a period of 3 years, and also in acute experiments in which subjects were exposed to 6 and 37 C for up to 2 hr. Variations in the acetylating ability of blood may reflect the activity of metabolic mechanisms involved in thermal homeostasis.

aromatic amines; p-aminobenzoic acid; cold; heat acclimatization; (blood) enzymes; weather; environment

Submitted on September 11, 1962






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