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J Appl Physiol 18: 888-894, 1963;
8750-7587/63 $5.00
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Oxygen washout studies in the anesthetized dog

D. B. Cater 1, D. W. Hill 1, P. J. Lindop 1, J. F. Nunn 1, and I. A. Silver 1

1 Department of Radiotherapeutics, and Sub-Department of Veterinary Anatomy, University of Cambridge, Research Department of Anaesthetics, Royal College of Surgeons of England, and Radiobiology Unit, Medical College of St. Bartholomew's Hospital, London, England

To evaluate technique for producing hypoxia in patients during radiotherapy, anesthetized dogs were hyperventilated with N2 for 3 min. End-tidal Po2 fell rapidly to near zero, but arterial Po2 fell to 10 mm Hg with mixed venous Po2 fractionally higher. Mean tissue Po2 of cortical gray matter fell to 0.7 mm Hg, white matter to 1.7, and subcutaneous tissue to 1.8, but muscle fell only to 7.8 mm Hg. Reasons for failure of oxygen washout are discussed.

N2 inhalation; radiosensitivity; muscle Po2; brain Po2; tissue Po2; polarography; cerebral cortical cell inhibition; arterio-venous Po2

Submitted on October 25, 1962






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