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J Appl Physiol 18: 877-880, 1963;
8750-7587/63 $5.00
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Acid-base changes in the fetal lamb before and after lung expansion

N. S. Assali 1, W. A. Manson 1, L. W. Holm 1, and M. Ross 1

1 Departments of Obstetrics and Gynecology and of Physiology, University of California School of Medicine, Los Angeles, and Department of Physiology, University of California School of Veterinary Medicine, Davis, California

The acid-base status of the fetal lamb was studied in near-term pregnant ewes subjected to spinal anesthesia. The status of the fetus was compared to its mother and the changes which occur after the fetal lungs were ventilated with oxygen or nitrogen were investigated. The results show that: 1) the fetus in utero is in a state of metabolic acidosis in relation to the mother, 2) the acidosis does not seem to be related to the fetal blood pCO2, and 3) the acidosis may be aggravated by hypoxia.

fetal acidosis; blood pH; blood oxygen; blood carbon dioxide; hypoxia; hyperoxia; sheep

Submitted on March 20, 1963




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J. L. McNay and P. G. Dayton
Placental Transfer of a Substituted Pteridine from Fetus to Mother
Science, February 13, 1970; 167(3920): 988 - 990.
[Abstract] [PDF]


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