Cerebrospinal fluid acid-base balance during a changing ventilatory state in man

¹ Cardiopulmonary Laboratory, Veterans Administration Hospital, New York City

Comparison of the rate and magnitude of changes in pH, CO₂ tension, and bicarbonate concentration in arterial blood, cisternal spinal fluid, and lumbar spinal fluid was made in man during hyperventilation and recovery. CO₂ tension changes in cisternal fluid were rapid and significant, although less in magnitude than those in arterial blood, whereas changes in lumbar fluid CO₂ tension were minimal and slow, lagging behind cisternal changes by 10–20 min. The different rates of change following altered ventilation explain some of the reported reversals of the normal lumbar spinal fluid to arterial blood CO₂ tension gradients. It also suggests that the choroid plexus is one site of removal of CO₂ from spinal fluid.

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				J. B. POSNER, A. G. SWANSON, and F. PLUM Acid-Base Balance in Cerebrospinal Fluid Arch Neurol, May 1, 1965; 12(5): 479 - 496. [Abstract] [PDF]