Journal of Applied Physiology
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J Appl Physiol 18: 557-559, 1963;
8750-7587/63 $5.00
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Relation between pressure and diameter in main pulmonary artery of man

Joseph C. Greenfield JR. 1 and Douglas M. Griggs JR. 1

1 Section of Clinical Biophysics, Cardiology Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland

The pressure-diameter relationship in the main pulmonary artery of man was estimated in 11 patients undergoing open-heart surgery. The diameter was measured with a recording caliper sutured to the vessel wall. The lateral intravascular pressure was measured with a 20-gauge needle connected directly to a Statham P23Db strain gauge. In the eight patients with normal pulmonary artery pressure the results indicate: 1) the shapes of the pressure and diameter curves are similar; 2) the mean value for the ratio of change in radius to change in pressure (DeltaR/DeltaP) x 103 was 8.77 cm/cm H2O (±sd 2.10); 3) the mean value for the pressure-strain elastic modulus (Ep) was 159.0 g/cm2sd 26.0); and 4) the mean change in cross-sectional area during an average cardiac cycle was 22.9% of the diastolic value. In three patients with pulmonary hypertension the value of both DeltaR/DeltaP and the pressure-strain elastic modulus was lower.

Submitted on April 27, 1962




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