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J Appl Physiol 18: 345-348, 1963;
8750-7587/63 $5.00
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Evidence that the Pco2 of mixed venous blood is not a regulator of ventilation during exercise

Winnifred F. Storey 1 and John Butler 1

1 Cardiovascular Research Institute, University of California School of Medicine, San Francisco, California

We studied 10 patients with intracardiac left-to-right shunt and 13 patients with other cardiac lesions during exercise. The hyperpnea of muscular exercise was independent of the mixed venous Pco2. In the 13 patients without shunt both the pulmonary arterial Pco2 and the ventilation increased during exercise. In the 10 patients who had shunts ventilation increased during exercise even when the Pco2 in the pulmonary arterial blood did not rise.

Submitted on July 5, 1962






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