Journal of Applied Physiology
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J Appl Physiol 17: 613-616, 1962;
8750-7587/62 $5.00
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Mechanism of bronchoconstriction during inhalation of dust

John G. Widdicombe 1, Donald C. Kent 1, and Jay A. Nadel 1

1 Cardiovascular Research Institute, University of California School of Medicine, San Francisco, California

Inhalation of fine charcoal dust decreased airway conductance (increased resistance) in man. Subcutaneous injection of atropine blocked this effect. In paralyzed and artificially ventilated cats, inhalation of dust increased total pulmonary airflow resistance. This was prevented by blocking conduction in the cervical vagosympathetic nerves. Inhalation of dust stimulated activity in single afferent nerve fibers arising in the trachea and also increased activity in efferent parasympathetic nerve fibers going to the lungs. These results establish the reflex nature of bronchoconstriction during inhalation of dust and show its dependence on the cervical vagosympathetic nerves.

Submitted on February 1, 1962




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