Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 17: 381-390, 1962;
8750-7587/62 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Staub, N. C.
Right arrow Articles by Storey, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Staub, N. C.
Right arrow Articles by Storey, W. F.

Relation between morphological and physiological events in lung studied by rapid freezing

Norman C. Staub 1 and Winnifred F. Storey 1

1 Cardiovascular Research Institute, University of California Medical Center, San Francisco, California

We have applied the method of rapid freezing to the living ventilated lung in the open thorax of cats. Studies in isolated lung lobes showed freezing to depths of 0.1 cm in less than frac12 sec, 0.2 cm in 2 sec. Theoretical calculations based on an idealized model and the experimental data are compared. At these fast rates, ice crystal formation is submicronic and light microscopy shows good histological preservation. We discuss the problem of whether the lung tissues respond to rapid cooling by any detectible alterations of structural form. Indirect evidence from our own and other studies suggests that there is little or no reaction, although further work along this line is necessary. We believe this procedure has important uses as a way to relate structural and functional details within the lung.

Submitted on September 5, 1961




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. E. Soutiere and W. Mitzner
On defining total lung capacity in the mouse
J Appl Physiol, May 1, 2004; 96(5): 1658 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. K. Nabors, W. A. Baumgartner Jr., S. J. Janke, J. R. Rose, W. W. Wagner Jr., and R. L. Capen
Red blood cell orientation in pulmonary capillaries and its effect on gas diffusion
J Appl Physiol, April 1, 2003; 94(4): 1634 - 1640.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Nagase, T. Aoki, T. Oka, Y. Fukuchi, and Y. Ouchi
ET-1-induced bronchoconstriction is mediated via ETB receptor in mice
J Appl Physiol, July 1, 1997; 83(1): 46 - 51.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online