Comparison of two iminodibenzil derivatives on restraint-induced ulcers and gastric secretion

¹ Gastroenterology Center, Bichat Hospital; and Gastrointestinal Research Clinic, National Hygiene Institute, Paris, France

Imipramine [N-(-dimethylaminopropyl)-iminodibenzyl HCl] was effective in reducing both the incidence of ulcers induced by several different intensities of restraint stress and the volume and acidity of gastric secretion in the rat. G 31.002 [N-(-dimethylaminoisopropyl)-iminodibenzyl HCl], a close congener of imipramine, was studied at comparable doses, but did not alter ulcer incidence or reduce gastric secretion. Since both drugs have similar central nervous system depressant activity, the data suggest that the antiulcer effect of imipramine is due to a direct action on the stomach.