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J Appl Physiol 17: 6-8, 1962;
8750-7587/62 $5.00
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Effect of acetazolamide on respiratory gas exchange during hyperventilation in man

Johan H. Strömme 1 and J. Fog 1

1 Institute of Aviation Medicine, Royal Norwegian Air Force, Oslo, Norway

The effects of acetazolamide on the CO2 output and on the O2 uptake during hyperventilation have been investigated. Nine healthy men were given acetazolamide orally in doses of 10–12 mg/kg body wt. All showed a decrease in CO2 output during hyperventilation performed 2 hr after the dosage as compared to values obtained in tests without premedication. The mean reduction was about 12%. During these tests no significant change was recorded in the O2 uptake. The decreased output of CO2 is presumed to be caused by an inhibition by acetazolamide of the carbonic anhydrase present in the erythrocytes.

Submitted on May 12, 1961






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