Journal of Applied Physiology
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J Appl Physiol 17: 21-27, 1962;
8750-7587/62 $5.00
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Importance of diffusion and chemical reaction rates in O2 uptake in the lung

N. C. Staub 1, J. M. Bishop 1, and R. E. Forster 1

1 Cardiovascular Research Institute, University of California Medical Center, San Francisco, California; and Department of Physiology, Graduate School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

The Bohr integration procedure for the approximate solution of the blood O2 tension along the pulmonary capillary from known values of alveolar, mixed venous, and end capillary O2 tensions and the O2 hemoglobin dissociation curve assumes, among other things, that the dissolved O2 in the blood is always in equilibrium with the hemoglobin, in other words that the exchange of O2 between the red cells and the plasma is instantaneous. Previous work (J. Appl. Physiol. 16: 511, 1961) has shown that, on the contrary, the experimentally measured rates of O2 uptake of the red cells are slow enough to limit the uptake of this gas in the alveolar capillaries. Therefore we have developed a method analogous to the Bohr integration for obtaining an approximate solution for the O2 tension of the plasma and of the red cells along the pulmonary capillary where Dl is a function of O2Hb saturation. Examples are given for a normal individual and an individual with severe anemia both breathing air and 14% O2.

Submitted on July 18, 1961




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