Journal of Applied Physiology
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J Appl Physiol 16: 1023-1028, 1961;
8750-7587/61 $5.00
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Carbon dioxide transport in anesthetized dogs during inhibition of carbonic anhydrase

Stephen M. Cain 1 and Arthur B. Otis 1

1 Department of Physiology, University of Florida College of Medicine, Gainesville, Florida

Following inhibition of blood carbonic anhydrase by acetazolamide in anesthetized dogs with one lung rebreathing in connection with a bag and with the other lung ventilating freely on pure oxygen, mixed venous Pco2 increased and alveolar Pco2 decreased. Carbon dioxide output dropped initially but gradually rose and attained a steady state value equal to that of the initial control condition. Before acetazolamide, 19% of the pulmonary CO2 output was derived from dissolved CO2, 26% from carbamino compound, and 55% from bicarbonate. In the new steady state following acetazolamide, 45% came from dissolved CO2, 38% from carbamino, and 17% from bicarbonate.

Submitted on June 12, 1961




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