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J Appl Physiol 16: 847-850, 1961;
8750-7587/61 $5.00
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Mean corpuscular hemoglobin concentration in anoxic lung disease

D. Verel 1 and D. F. Kerridge 1

1 The Regional Cardiovascular Unit, City General Hospital; and Department of Statistics, University of Sheffield, Sheffield, England

An analysis of patients suffering from polycythemia rubra vera, congenital heart disease, and anoxic lung disease is presented. The effect on the mean corpuscular hemoglobin concentration (MCHC) of anoxia and increased erythropoesis is compared. The results suggest that in chronic anoxic lung disease both desaturation and increased erythropoesis may play a part in lowering the MCHC. A statistically significant relation exists between the low MCHC and increased pCO2 in addition. A discriminate analysis suggests that additional factors also play a part.

Submitted on December 22, 1960






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