Journal of Applied Physiology
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J Appl Physiol 16: 720-722, 1961;
8750-7587/61 $5.00
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Excretion of nitrous oxide in anesthetized man

M. Jack Frumin 1, Ernest Salanitre 1, and Herbert Rackow 1

1 Department of Anesthesiology, Columbia University, College of Physicians and Surgeons; and the Anesthesiology Service, The Presbyterian Hospital, New York City

The elimination of N2O was studied in anesthetized man in order to define the excretion process. The end-tidal concentrations of N2O were determined for approximately 30 min during washout produced by breathing air at rates of alveolar ventilation producing end-tidal CO2 tensions of approximately 40 mm Hg. The average excretion curve was resolved into three exponentials and the constants determined.

Submitted on February 6, 1961






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