Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 16: 549-552, 1961;
8750-7587/61 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feisal, K. A.
Right arrow Articles by Keasling, H. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feisal, K. A.
Right arrow Articles by Keasling, H. H.

Effects of chlorothiazide on forearm vascular responses to norepinephrine

Khalil A. Feisal 1, John W. Eckstein 1, A. W. Horsley 1, and Hugh H. Keasling 1

1 Cardiovascular Research Laboratories, Department of Internal Medicine; and Department of Pharmacology, State University of Iowa College of Medicine, Iowa City, Iowa

The effects of graded doses of norepinephrine on pulse rate, mean blood pressure, forearm blood flow and vascular resistance were studied in normal human subjects before, during, and after chronic administration of chlorothiazide. This drug prevented the negative chronotropic response normally induced by norepinephrine without altering the pressor response. Before giving and after discontinuing chlorothiazide, increasing doses of norepinephrine were associated with progressive decreases in blood flow. After 1 week of chlorothiazide administration, increasing doses of norepinephrine were associated with increases in flow. The results indicate that chlorothiazide decreases the responsiveness of the forearm vessels of normal subjects to the vasoconstrictor effect of norepinephrine. They suggest that chlorothiazide also may modify the effect of norepinephrine on cardiac output.

Submitted on December 9, 1960




This article has been cited by other articles:


Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
A. D Hughes
How do thiazide and thiazide-like diuretics lower blood pressure?
Journal of Renin-Angiotensin-Aldosterone System, December 1, 2004; 5(4): 155 - 160.
[Abstract] [PDF]

Home page
 HypertensionHome page
P. Pickkers, A. D. Hughes, F. G. M. Russel, T. Thien, and P. Smits
Thiazide-Induced Vasodilation in Humans Is Mediated by Potassium Channel Activation
Hypertension, December 1, 1998; 32(6): 1071 - 1076.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online