Journal of Applied Physiology
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J Appl Physiol 16: 511-516, 1961;
8750-7587/61 $5.00
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Velocity of O2 uptake by human red blood cells

N. C. Staub 1, J. M. Bishop 1, and R. E. Forster 1

1 Cardiovascular Research Institute, University of California Medical Center, San Francisco, California; and Department of Physiology, University of Pennsylvania Graduate School of Medicine, Philadelphia, Pennsylvania

We have determined the over-all association rate constant, k'c, for the uptake of oxygen by normal human erythrocytes from 0% to 97% initial hemoglobin saturation at pH 7.4 and 37°C. With a modified Hartridge-Roughton rapid-reaction apparatus, we used a small oxygen electrode to follow the oxygen uptake process rather than using the usual photocolorimetric analytical methods. The value of k'c averages 164 mm–1 sec.–1 at 0% initial saturation, rises slowly to over 300 at 50%, and then climbs rapidly to over 1500 at 95%. The theoretical explanation for the increase in k'c with rising initial oxyhemoglobin saturation is based on the increasing prominence of the fourth chemical association rate constant, k'4, in the intermediate compound theory of Adair. It is known that k'4 is several times larger than any of the other three k's.

Submitted on December 19, 1960




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