Journal of Applied Physiology
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J Appl Physiol 16: 507-510, 1961;
8750-7587/61 $5.00
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Variations of ventilation and diffusing capacity to perfusion determining the alveolar-arterial O2 difference: theory

Johannes Piiper 1

1 Department of Physiology, University of Buffalo School of Medicine, Buffalo, New York

The factors determining the alveolar-arterial O2 pressure difference, AaD, have been theoretically reinvestigated, taking into account the effect of unequal distribution of pulmonary diffusing capacity, D, to pulmonary perfusion, Q. It is shown that, for a given inspired gas and a given mixed venous blood, the AaD is determined by two parameters, the ratios diffusing capacity :perfusion, D/Q, and alveolar ventilation :perfusion, Va/Q. Two characteristics of both of these ratios, the mean value and the variation, affect the AaD.

Submitted on May 23, 1960






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