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J Appl Physiol 16: 488-492, 1961;
8750-7587/61 $5.00
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Gas exchange after autologous pulmonary embolism in dogs

Myron Stein 1, Claude E. Forkner JR. 1, Eugene D. Robin 1, and Stanford Wessler 1

1 Department of Medicine, Harvard Medical School; Departments of Medical Research, Beth Israel Hospital; and Medical Clinics, Peter Bent Brigham Hospital, Boston, Massachusetts

The ventilatory and arterial blood gas responses to serum-induced thrombi embolized to the pulmonary circulation of the dog have been measured. An increase in rate and minute volume of ventilation independent of the extent of the pulmonary artery obstruction were almost invariably observed. The release of thrombi to the lungs was associated with an arterial-alveolar CO2 tension difference that was dependent on the extent of arterial obstruction. Significant decreases in arterial O2 saturation occurred in animals with massive embolization in the presence of a total minute and alveolar ventilation significantly greater than control values. Failure of arterial O2 concentration to rise to control levels after inhalation of 99.6% O2 indicated that emboli of the dogs' own blood produced a perfusion defect consistent with a right to left shunt.

Submitted on November 21, 1960




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W. A. Altemeier, H. T. Robertson, S. McKinney, and R. W. Glenny
Pulmonary embolization causes hypoxemia by redistributing regional blood flow without changing ventilation
J Appl Physiol, December 1, 1998; 85(6): 2337 - 2343.
[Abstract] [Full Text] [PDF]


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