Journal of Applied Physiology
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J Appl Physiol 16: 463-464, 1961;
8750-7587/61 $5.00
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Measurement of dynamic resistance to breathing in unanesthetized dogs

Fred J. McIlreath JR. 1, Albert B. Craig JR. 1, and Anthony J. Anzalone 1

1 Department of Pharmacology, Strasenburgh Laboratories; and Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Measurements of air-flow resistance were made using unanesthetized dogs prepared with exteriorized tracheas. Pressure-flow relationships obtained from these experiments adhered to Rohrer's equation. Drugs that are classically known to alter tone of bronchial musculature substantially change the pressure-flow relationship in these animals.

Submitted on October 6, 1960






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