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1 Departments of Medicine and Environmental Medicine, Johns Hopkins University, Baltimore, Maryland
It was shown that in excised lungs of dogs the effect of changing the degree of inflation of the lung was to change the static volume-pressure curve of the pulmonary vascular bed in shape, slope, and position. The data show that there is no simple answer to the question: does the pulmonary vascular bed get bigger or smaller with inflation of the lung? If vascular pressure was held constant when transpulmonary pressure was changed from 0 to 30 cm H2O, vascular volume increased when vascular pressure was low and decreased when vascular pressure was high. In addition, when vascular pressure was held constant, vascular volume changed in an opposite way depending on whether transpulmonary pressure was changed from low to moderate values or from moderate to high values.
Submitted on June 9, 1960
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