Journal of Applied Physiology
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J Appl Physiol 16: 181-185, 1961;
8750-7587/61 $5.00
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Water exchange in animal and human tumors

Jack H. Bloch 1, Florence K. Millar 1, Alvin R. Harris 1, Nathaniel I. Berlin 1, and Julius White 1

1 Surgery and General Medicine Branches and Laboratory of Physiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

The equilibration of tritiated water in the blood with the water of nine tumors of wide histologic variety and anatomic location in four different host species, rat, mouse, hamster and man, was studied following intravenous injection of labeled water. Evidence is presented that the rate of water exchange for eight of these tumors is essentially the same; that tumor water in comparison with liver, muscle and skin equilibrates slowly with blood water; that the major limiting factor in this exchange is blood supply; and that the rate of water exchange in the tumor is increased by ether anesthesia.

Submitted on August 9, 1960






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