Journal of Applied Physiology
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J Appl Physiol 15: 454-458, 1960;
8750-7587/60 $5.00
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Effect of CO2 inhalation on arterial pressure, ECG and plasma catecholamines and 17-OH corticosteroids in normal man

P. H. Sechzer 1, L. D. Egbert 1, H. W. Linde 1, D. Y. Cooper 1, R. D. Dripps 1, and H. L. Price 1

1 Department of Anesthesiology and Harrison Department of Surgical Research, University of Pennsylvania Schools of Medicine, Philadelphia, Pennsylvania

Twelve male volunteers inspired concentrations of carbon dioxide in oxygen ranging from 7% to 14% for periods of 10–20 minutes. Respiratory minute volume, arterial pressure, heart rate, and plasma concentrations of epinephrine, norepinephrine and 17-OH corticosteroids were increased in every subject during hypercarbia. Abnormal cardiac rhythm was infrequently observed. Following substitution of oxygen for the carbon dioxide-oxygen mixture, the altered measurements returned to normal over a period of roughly 10 minutes. Neither marked hypotension nor cardiac arrhythmia was observed after correction of hypercarbia.

Submitted on January 8, 1960




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