Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 15: 383-389, 1960;
8750-7587/60 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nunn, J. F.
Right arrow Articles by Hill, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nunn, J. F.
Right arrow Articles by Hill, D. W.

Respiratory dead space and arterial to end-tidal CO2 tension difference in anesthetized man

J. F. Nunn 1 and D. W. Hill 1

1 Research Department of Anaesthetics, Royal College of Surgeons of England; and Department of Anaesthetics, Whittington Hospital, London, England

Observations were made during both spontaneous and artificial respiration on 12 fit patients anesthetized for routine surgical procedures. Above a tidal volume of 350 ml (BTPS), the anatomical dead space was close to the predicted normal value for the subject. Below 350 ml, it was reduced in proportion to the tidal volume. The physiological dead space (below the carina) approximated to 0.3 times the tidal volume for tidal volumes between 163 and 652 ml (BTPS). Throughout the range the physiological dead space was considerably in excess of the anatomical dead space measured simultaneously. The difference (alveolar dead space) varied from 15 to 231 ml, being roughly proportional to the tidal volume. The mean arterial to end-tidal CO2 tension difference was 4.6 (S.D. ±2.5) mm Hg and not related to tidal volume or arterial CO2 tension. None of the findings appeared to depend on whether the respiration was spontaneous or artificial.

Submitted on September 25, 1959




This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
G. A. Bellingham, A. K. Dhir, and P. P. Luke
Case report: Retroperitoneoscopic pheochromocytoma removal in an adult with Eisenmenger's syndrome: [Presentation de cas : Ablation retroperitoneoscopique d'un pheochromocytome chez un adulte souffrant du syndrome d'Eisenmenger]
Can J Anesth, May 1, 2008; 55(5): 295 - 301.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
I. Kwetny and B. T. Finucane
Negative arterial to end-tidal carbon dioxide gradient: an additional sign of malignant hyperthermia during desflurane anesthesia.
Anesth. Analg., March 1, 2006; 102(3): 815 - 817.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
I. K. Moppett, C. B. Gornall, and J. G. Hardman
The dependence of measured alveolar deadspace on anatomical deadspace volume
Br. J. Anaesth., September 1, 2005; 95(3): 400 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. G. Hardman and A. R. Aitkenhead
Validation of an Original Mathematical Model of CO2 Elimination and Dead Space Ventilation
Anesth. Analg., December 1, 2003; 97(6): 1840 - 1845.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. G. Hardman and A. R. Aitkenhead
Estimating Alveolar Dead Space from the Arterial to End-Tidal CO2 Gradient: A Modeling Analysis
Anesth. Analg., December 1, 2003; 97(6): 1846 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Oshibuchi, S. Cho, T. Hara, S. Tomiyasu, T. Makita, and K. Sumikawa
A Comparative Evaluation of Transcutaneous and End-Tidal Measurements of CO2 in Thoracic Anesthesia
Anesth. Analg., September 1, 2003; 97(3): 776 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. J. Mummery, B. W. Stolp, G. deL. Dear, P. O. Doar, M. J. Natoli, A. E. Boso, J. D. Archibald, G. W. Hobbs, H. E. El-Moalem, and R. E. Moon
Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATA
J Appl Physiol, February 1, 2003; 94(2): 507 - 517.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. Tanabe, Y. Hosaka, M. Ito, E. Ito, and K. Suzuki
Significance of End-Tidal PCO2 Response to Exercise and Its Relation to Functional Capacity in Patients With Chronic Heart Failure
Chest, March 1, 2001; 119(3): 811 - 817.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
C. M. MURDOCK, A. J. WOLFF, and T. VAN GEEM
Risk Factors for Hypercarbia, Subcutaneous Emphysema, Pneumothorax, and Pneumomediastinum During Laparoscopy
Obstet. Gynecol., May 1, 2000; 95(5): 704 - 709.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
J. T. Anderson, J. T. Owings, and J. E. Goodnight
Bedside Noninvasive Detection of Acute Pulmonary Embolism in Critically Ill Surgical Patients
Arch Surg, August 1, 1999; 134(8): 869 - 875.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
B. Grenier, E. Verchere, A. Mesli, M. Dubreuil, D. Siao, M. Vandendriessche, J. Cales, and P. Maurette
Capnography Monitoring During Neurosurgery: Reliability in Relation to Various Intraoperative Positions
Anesth. Analg., January 1, 1999; 88(1): 43 - 48.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Dumville, R. B. Panerai, N. S. Lennard, A. R. Naylor, and D. H. Evans
Can Cerebrovascular Reactivity Be Assessed Without Measuring Blood Pressure in Patients With Carotid Artery Disease?
Stroke, May 1, 1998; 29(5): 968 - 974.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online