Journal of Applied Physiology
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J Appl Physiol 15: 291-294, 1960;
8750-7587/60 $5.00
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Use of the restrained rat technique for study of the antiulcer effect of drugs

H. M. Hanson 1 and D. A. Brodie 1

1 Merck Institute for Therapeutic Research, West Point, Pennsylvania

Five anticholinergic drugs, atropine sulfate, diphenmethanil, mepiperphenidol, propantheline and scopolamine methiodide, were studied for their effects on gastric ulcers in rats produced by the restraint technique. All the drugs significantly decreased ulceration; scopolamine methiodide appeared to be the most potent drug tested, followed by propantheline, atropine, diphenmethanil and mepiperphenidol. Three central nervous system depressants, chlorpromazine, benactyzine and pentobarbital, all decreased the incidence of ulcers with no differences in potency. Acetazolamide administered daily for 5 days had no effect on ulceration. Prednisolone administered daily was found to increase the time required for recovery from restraint-produced ulcers.

Submitted on November 6, 1959






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