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J Appl Physiol 15: 280-282, 1960;
8750-7587/60 $5.00
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Effect of sleep deprivation on plasma 17-hydroxycorticosteroids

Benjamin J. Murawski 1 and Jean Crabbé 1

1 Department of Medicine, Harvard Medical School, and Medical Clinic, Peter Bent Brigham Hospital, Boston, Massachusetts

Paid volunteers, 18 male college students, were deprived of sleep for one night on two separate occasions when alone. On a third occasion they were asked to stay up all night in groups of four. Plasma concentrations of 17-hydroxycorticosteroids at 8:00 a.m. following the nights without sleep were 4–5 µg lower than control values (significant at .01 level). The noon values after sleep deprivation in a solitary setting were not significantly different from the corresponding control values. When subjects stayed up with three other people, the noon values tended to be higher. Urinary 17-hydroxycorticosteroid levels showed a decrease following the nights without sleep, but this decrease did not reach statistical significance (between the .10–.05 level).

Submitted on May 21, 1959




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[Abstract] [PDF]


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