Journal of Applied Physiology
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J Appl Physiol 14: 949-950, 1959;
8750-7587/59 $5.00
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Paradoxical effect of an orally ingested histamine analogue on capillaries and arteriovenous anastomoses of the human digit

Nosrat Naftchi 1, Milton Mendlowitz 1, Herbert L. Weinreb 1, and Stanley Gitlow 1

1 Andre Meyer Department of Physics and Department of Medicine, Mount Sinai Hospital, New York City

The effect on the circulation of an orally ingested histamine analogue was studied in nine human subjects, and of subcutaneously administered histamine phosphate in four human subjects. In the digit, a paradoxical effect was observed consisting of capillary and venular dilatation and constriction of arteriovenous anastomoses. The latter effect was probably a reflex response to heat loss caused by the generalized dermal capillary dilatation which was the direct effect of the drug.

Submitted on March 18, 1959






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