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J Appl Physiol 14: 694-700, 1959;
8750-7587/59 $5.00
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Alveolar-arterial O2 differences during artificial respiration in man

M. Jack Frumin 1, Norman A. Bergman 1, Duncan A. Holaday 1, Herbert Rackow 1, and Ernest Salanitre 1

1 Department of Anesthesiology, Columbia University College of Physicians and Surgeons, and The Presbyterian Hospital, New York City

Alveolar-arterial oxygen differences were determined in anesthetized, paralyzed man. Approximately 20% of the determinations showed a Pa-a O2 of greater than 20 mm Hg. The arterial tension rose an average of 10 mm Hg when the expiratory pressure was increased from –5 to +5 mm Hg. The insertion of a 3-mm orifice expiratory resistance increased the arterial O2 tension an average of 7 mm Hg. The causes for these variations in arterial O2 tension and saturation are discussed. The functional residual capacity at +5 and –5 mm Hg expiratory pressure were determined by the nitrogen washout technique. The theoretically expected changes in alveolar O2 tension due to differences in the functional residual capacity accounted for only a third or less of the experimentally observed changes in arterial saturations and tensions.

Submitted on February 6, 1959




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